Robert’s Working Blog

1. y=a+b/x2
2.  y=a+b/x1.5
3. y=a+b/x
4. y=a+b/x0.5
5.  y=a+b/lnx
6.  y=a+blnx
7.  y=a+bx

1.I only focus on “CRH” and “CRH-BP”
2. Compare the data value can judge the decreasing period (literature survey shows it starting at the third trimester)<– we need to prove it

CRH-BP
PSN=85 deleted (one sample)
PSN=167 deleted (only one sample)
PSN=169 deleted (one sample)
PSN=238 deleted (one sample)

1. focus on spontaneous labour only
2. concentrate on 26 weeks CRH blood hormone level
3. cut off criteria less than 90pm for term, >90pm for preterm

4. Risk factors for preterm delivery include previous preterm
delivery, infection, smoking, uterine abnormalities, multiple
gestation, polyhydramnios, and such demographic variables
as extremes of maternal age, social class, race, and low body
weight (30). Other biochemical markers used in an attempt
to improve the prediction of preterm labor include estriol
(31), activin (21), cytokines (32), fibronectin (33), collagenase
(34), and tissue inhibitors of metalloproteinases (35). To date,
there has been no test, either alone or in combination, that has
provided a clinically useful predictor of preterm delivery
(20, 36).

5. The current study was not designed to investigate the
mechanism by which CRH may play a role in the initiation
of labor and delivery. Several investigators have examined
this in detail (16). First, CRH increases the production of PGs,
known to stimulate myometrial contraction, from the placenta
and fetal membranes (39). Second, CRH may modulate
the maturation of the fetal hypothalamic pituitary adrenal
axis, resulting in fetal cortisol and DHEA production. Cortisol
plays an important function in the regulation of PGsynthesizing
enzymes and also further enhances placental
CRH expression (40). Third, CRH has been demonstrated to
be a potent vasodilator and may be involved as a regulator
of placental vascular tone (41, 42). Finally, CRH may interact
directly with specific myometrial receptor subtypes that are
up-regulated during pregnancy (43). CRH may have a dual
role, by facilitating myometrial quiescence during pregnancy,
followed by augmentation of PG and oxytocininduced
contractility during labor (16).

1. smoking
2. gender
3. type of labor
4. ethnicity (aborginal)
5. parity
6. birth weight
7. DOB
8. height
9. bp at booking
10. gestational diabetes screening

I need to:
1. investigate relationship of median trajectory (correlation)
2. program on risk factor and analyze risk factors above
3. take a look “cortisol” wrong scale

1.
PSN=145
PSN=202
has only 1 samples, so has been deleted.
2. The new created file “NZ15SEP08.map”, only individual data set is reliable

3. PSN=291 has less than 3 points and deleted

1. y=a+bx^2
2. y=a+bx^1.5
3. y=a+bx^2.5
4. y=a+bx^3
5. y=aexp(-x/b)
6. y=a+bexp(-x/c)

From tablecurve 2d software points of view, the best equation may be (1). Needs to be confirmed during actual curve fitting and residuals

1. CRH only (Pmol/L)

1. Professor Gus Dekker , Obstetrics and Gynaecology

1. probably plot 3D plot for 2 blood hormones to see the relationship (CRH-Prog-Time)
2. think about a way to analyze “correlation” between trajectories (focus on a single time point)
3. try to plot the different between preterm and term (in percentage) for all eight blood hormone and identify a key time point
4. think about other quality measurement